Analytical characterization of AAV for clinical and commercial applications is rudimentary, although health authorities have been pushing sponsors to make these assays more discerning and robust. The Wilson lab has been at the forefront of this evolving story, driving the analytical and regulatory science. Examples include the development of digital PCR for assessment of genome titers and the definition of post-translational modifications and its analysis by mass spectrometry. The Wilson lab has provided analytical support to numerous alliance partners.
