Now offering adenovirus and lentivirus production services! Learn More
AAV Research Vector Packaging Services
Franklin Biolabs delivers superior AAV research vector packaging services to support your advanced therapy program.
Penn Vector Core Transfer
Certain vector manufacturing capabilities previously provided by the Penn Vector Core of the Gene Therapy Program at the University of Pennsylvania have been acquired by Franklin Biolabs, and such services are now available via Franklin Biolabs.
Fast, Quality Research Vector Production
Our well-established team has decades of experience manufacturing wild type and engineered serotypes, specializing in the production of novel and refractory capsids. With unmatched expertise in AAV manufacturing and concierge-style service, hundreds of customers return to us for their next project. Franklin Biolabs delivers high quality vectors worldwide. The team has supported preclinical studies for gene therapies as part of global investigational new drug (IND) submissions that were approved and are now in clinical trials.
We greatly appreciate the Research Vector team’s professionalism, responsiveness, and high-quality deliverables at Franklin Biolabs, which significantly contributed to smooth execution of our project. Highly recommended!”
Expanded Services – Adenovirus and Lentivirus
Our experienced team has expanded their service offerings to include adenovirus and lentivirus
production. We are excited to support an extensive range of cell and gene therapy projects with these
additional modalities, including CAR-T applications, oncolytic programs, and vaccines.
For more information, please connect with us.
Flexible, Scalable Platform
Our customizable AAV packaging services can meet your project needs for production scale, purification level, and QC analytics. We offer a full range of DNA services that includes cloning, amplification, characterization, and gene synthesis support.
Key benefits include:
- Numerous serotypes available including AAV1/2/5/8/9 and >75 engineered serotypes
- High yield products [construct dependent]
- High purity
- Low endotoxin for in vivo experiments
- Fast turnaround
- Wide range of QC analytics options available
- Extensive technical support
- Frequent updates and progress reports
- Superb customer service
Streamlined Production, Seamless Experience
Our team can produce your research vector in 3-4 weeks for routine orders and up to 8 weeks for custom designs. With a commitment to transparency and state-of-the-art logistics, our research vector team provides customers with a boutique experience.
With extensive experience successfully packaging thousands of different products, our team is ready to tackle any project. The group at Franklin can provide advice tailored to your specific aims and budget on features including construct design, serotype, volume, and purity. Note that additional time (2-3 weeks) is required for plasmid generation and cloning.
AAV is a powerful research tool and a highly effective vector for delivering genetic payloads in gene and cell therapies. AAV are non-pathogenic, minimally immunogenic, can target dividing and non-dividing cells, drive long-term gene expression, and are available in a wide range of natural and engineered serotypes. Your gene of interest is packaged into AAV vectors via triple transfection of HEK293 cells.
AAV particles are purified using iodixanol gradient ultracentrifugation to remove impurities and empty capsids; chromatography purification is also available. Viral titer is determined via digital droplet PCR. Franklin Biolabs purifies vector to the level appropriate for your in vivo or in vitro research application.
Franklin Biolabs offers an extensive range of validated QC assays to characterize the identity, purity, and potency of your AAV vector. Custom assay development is available. We are proud to share that our vector production runs generate critical quality attribute data ready for inclusion in regulatory submissions. Learn more about our analytical testing services here.
Our team has successfully delivered vector for in vivo and in vitro research to thousands of clients across five continents. The research vector team will ensure your vector is delivered safely and on time, so place an order with confidence.
Take the Next Step in AAV Research
Connect with our experts to discuss your research vector needs and accelerate the development of your gene therapy.
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Want to Accelerate
Your AAV Program
Even Quicker?
Check out our preclinical services to see Franklin Biolabs’ in vivo study services, including specialized routes of administration, biodistribution, and toxicology studies to evaluate your novel gene therapy.
Thinking of
Scaling Up
Production?
Check out our process development/large-scale production page for more information on how Franklin Biolabs can advance your gene therapy from discovery to commercialization.